361 papers
Cell biology is the study of life at its most fundamental unit: the cell. This field explores how these microscopic building blocks function, communicate, and replicate to sustain living organisms, from the simplest bacteria to complex human tissues. By understanding the machinery inside a cell, scientists unlock secrets about growth, disease, and the very nature of existence itself.
At Gist.Science, we track every new preprint uploaded to bioRxiv within this dynamic category. Our team processes each submission to provide both accessible plain-language explanations and detailed technical summaries, ensuring you can grasp complex discoveries without getting lost in dense jargon. Below are the latest papers in cell biology, offering a fresh look at the inner workings of life as they are shared with the world.
This study reveals that c-MYC is an aggregation-prone, amyloidogenic protein whose spontaneous formation of amyloid oligomers induces transcription-independent apoptosis, suggesting a built-in failsafe mechanism that contributes to its paradoxical tumor-suppressing activity.
Using live-imaging of over 150 HCT116 cell lineages, this study reveals that multipolar chromosome segregation in early mitosis is the primary factor limiting post-whole-genome duplication proliferation, with successful lineages either mitigating this risk in one sub-lineage or surviving despite early multipolar events.
This study reveals that gut tumors in *Drosophila* secrete Pvf1 to activate the TORC1-Hnf4 signaling pathway in distal hepatocyte-like oenocytes, reprogramming their lipid metabolism to produce specific fatty acids that fuel tracheal growth and tumor progression, a mechanism conserved in mammals that offers potential therapeutic targets for cancer-associated metabolic disorders.
This study demonstrates that while intrinsic internalization of positively charged protein cargos is charge-dependent and limited by surface saturation, the efficacy of calcium-dependent cell-penetrating peptide adaptors varies significantly based on cargo charge, with specific adaptor designs capable of overcoming these limits or inhibiting uptake depending on their own electrostatic properties.
This study demonstrates that synergistically inhibiting Notch signaling via Rbpj deletion and forcing Müller glia cell cycle re-entry through cyclin D1 overexpression and p27Kip1 suppression effectively drives the reprogramming of uninjured mouse Müller glia into long-surviving, subtype-specific retinal neurons.
This study demonstrates that NBR1, like its partner p62, shuttles between the cytoplasm and nucleus via specific signal motifs and is essential for the formation of nuclear p62 bodies.
This study reveals that clonal hematopoiesis driven by *TP53* mutations promotes tissue repair in acute cardiovascular diseases by enhancing the pro-angiogenic and phagocytic capabilities of mutant macrophages through suppressed E2F signaling and increased VEGF expression.
This study demonstrates that rapid dephosphorylation of HRS at ER-multivesicular endosome membrane contact sites, mediated by AnnexinA1 and the phosphatase PTP1B, is essential for efficient intraluminal vesicle formation and receptor sorting.
This study demonstrates that SUMO regulates meiotic chromosome architecture by inversely controlling chromatin loop size and axis length, thereby directly influencing crossover frequency and explaining physiological variations in recombination rates across sexes and species.
This study demonstrates that ARP2/3-mediated branched actin, rather than linear actin, is essential for segregating endosomal cargo into distinct subdomains, maintaining these domains, and driving the fission events required for receptor recycling at the early endosome.