414 papers
Cell biology is the study of life at its most fundamental unit: the cell. This field explores how these microscopic building blocks function, communicate, and replicate to sustain living organisms, from the simplest bacteria to complex human tissues. By understanding the machinery inside a cell, scientists unlock secrets about growth, disease, and the very nature of existence itself.
At Gist.Science, we track every new preprint uploaded to bioRxiv within this dynamic category. Our team processes each submission to provide both accessible plain-language explanations and detailed technical summaries, ensuring you can grasp complex discoveries without getting lost in dense jargon. Below are the latest papers in cell biology, offering a fresh look at the inner workings of life as they are shared with the world.
This study introduces a shotgun single-cell top-down proteomics strategy that successfully profiles diverse proteoforms in individual mouse cardiomyocytes, revealing substantial cell-to-cell molecular heterogeneity and establishing a powerful tool for understanding cardiac cellular identity and physiology.
This study identifies VIA1 as an evolutionarily conserved regulator that maintains thylakoid membrane integrity under high light stress by directly binding to and functioning with the ESCRT-III-like protein VIPP1.
This paper demonstrates that spatial heterogeneities in minimal stochastic reaction-diffusion models are sufficient to fundamentally reshape cell polarization dynamics, explaining phenomena like pole-to-pole oscillations and the New-End Take-Off through mechanisms of stochastic competition and finite cytoplasmic diffusion without requiring complex biochemical motifs.
This study demonstrates that in larval zebrafish, pharmacological vasodilation significantly reduces intracerebral haematoma size by confining red blood cells to affected vessels, whereas vasoconstriction does not exacerbate haemorrhage, thereby establishing vascular dilation as a key modulator of haemorrhage progression.
This study reveals that inhibiting V-ATPase triggers GCN1/GCN2-mediated integrated stress response and rapid MCL-1 depletion, leading to BAX/BAK-dependent apoptosis and creating a therapeutic vulnerability that synergizes with BH3 mimetics in MCL-1-dependent cancers.
This study reveals that axonal development relies on a novel Golgi-independent pathway where the axonal endoplasmic reticulum couples local transmembrane protein translation and secretion through a feedback loop involving HDLBP and the NRZ-SEC22B tethering complex to facilitate protein delivery to the axonal plasma membrane.
This study utilizes patient-derived human cardiac organoids to demonstrate that LMNA haploinsufficiency triggers early, reversible multicellular remodeling and profibrotic signaling prior to the onset of overt dilated cardiomyopathy, highlighting a potential window for therapeutic intervention.
This study reveals that the yeast transcription factor Cbf1 stabilizes the budding yeast kinetochore by forming an interdependent, mutually reinforcing interaction with the inner kinetochore protein Okp1, which is essential for both CCAN assembly and the protein's own stable centromeric association.
This study identifies the GPI-anchored protease MT4-MMP as a critical regulator of embryonic brain angiogenesis that maintains vascular balance by cleaving the co-receptor NRP1 to modulate VEGFA-induced ERK signaling, thereby preventing excessive vessel formation.
This study demonstrates that SUMO protein abundance positively correlates with and functionally regulates meiotic crossover rates across diverse vertebrate species and within goat breeds, establishing SUMO as a central mediator of genetic diversity and chromosome segregation.